Table 2.

Association between Midlife Cardiovascular Risk Factors and Traditional NP Outcome Measures.

Continuous Outcomes	Exposure
	FSRP Score		Age		Sex		Current Smoking		Diabetes		Hypertension		Prevalent CVD
	Beta (SE)	P-value	Beta (SE)	P-value	Beta (SE)	P-value	Beta (SE)	P-value	Beta (SE)	P-value	Beta (SE)	P-value	Beta (SE)	P-value
FAS – No. correct responses	−0.11 (0.10)	0.27	−0.29 (0.03)	<0.0001	3.0 (0.56)	<0.0001	−0.33 (0.75)	0.66	−3.3 (1.2)	0.007	−0.63 (0.65)*	0.34	−1.8 (1.3)	0.17
Animals – No. correct responses	−0.09 (0.04)	0.03	−0.21 (0.01)*	<0.0001	−0.32 (0.22)	0.14	−0.13 (0.30)	0.67	−0.96 (0.49)	0.05	−0.002 (0.26)*	0.99	−0.69 (0.52)	0.18
Trails B-A – Time to completion†	−0.008 (0.002)	0.0002	−0.01 (0.0007)	<0.0001	0.02 (0.01)	0.18	−0.01 (0.02)	0.44	−0.0009 (0.03)	0.97	−0.02 (0.01)	0.19	−0.05 (0.03)*	0.07
DS-B – Total score	−0.01 (0.01)	0.25	−0.01 (0.004)	0.0003	0.07 (0.07)	0.28	0.039 (0.088)	0.66	−0.24 (0.15)	0.09	0.046 (0.076)	0.54	0.057 (0.15)	0.71

Abbreviations: FSRP = Framingham Stroke Risk Profile; CVD = cardiovascular disease; OR = odds ratio; CI=confidence interval; SE=standard error; DS-B = Digit Span Backwards

Note: All models are adjusted for age, sex, education group (<high school degree, high school degree, college degree, >college degree), and time between risk factor measurement and neuropsychological testing. Sample size for each test is as follows: FAS (n=1706), Animals (n=1706), Trails B (n=1651), DS-B (n=1628).

^†Log transformed

^*Interaction with APOE genotype p<0.05

^**Interaction with APOE genotype p<0.01