Table 2.
Continuous Outcomes | Exposure | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FSRP Score | Age | Sex | Current Smoking | Diabetes | Hypertension | Prevalent CVD | ||||||||
Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | Beta (SE) | P-value | |
FAS – No. correct responses | −0.11 (0.10) | 0.27 | −0.29 (0.03) | <0.0001 | 3.0 (0.56) | <0.0001 | −0.33 (0.75) | 0.66 | −3.3 (1.2) | 0.007 | −0.63 (0.65)* | 0.34 | −1.8 (1.3) | 0.17 |
Animals – No. correct responses | −0.09 (0.04) | 0.03 | −0.21 (0.01)* | <0.0001 | −0.32 (0.22) | 0.14 | −0.13 (0.30) | 0.67 | −0.96 (0.49) | 0.05 | −0.002 (0.26)* | 0.99 | −0.69 (0.52) | 0.18 |
Trails B-A – Time to completion† | −0.008 (0.002) | 0.0002 | −0.01 (0.0007) | <0.0001 | 0.02 (0.01) | 0.18 | −0.01 (0.02) | 0.44 | −0.0009 (0.03) | 0.97 | −0.02 (0.01) | 0.19 | −0.05 (0.03)* | 0.07 |
DS-B – Total score | −0.01 (0.01) | 0.25 | −0.01 (0.004) | 0.0003 | 0.07 (0.07) | 0.28 | 0.039 (0.088) | 0.66 | −0.24 (0.15) | 0.09 | 0.046 (0.076) | 0.54 | 0.057 (0.15) | 0.71 |
Abbreviations: FSRP = Framingham Stroke Risk Profile; CVD = cardiovascular disease; OR = odds ratio; CI=confidence interval; SE=standard error; DS-B = Digit Span Backwards
Note: All models are adjusted for age, sex, education group (<high school degree, high school degree, college degree, >college degree), and time between risk factor measurement and neuropsychological testing. Sample size for each test is as follows: FAS (n=1706), Animals (n=1706), Trails B (n=1651), DS-B (n=1628).
Log transformed
Interaction with APOE genotype p<0.05
Interaction with APOE genotype p<0.01