Table 3.
Association between Midlife Cardiovascular Risk Factor and Error Response NP Outcome Measures
| Categorical Outcomes (≥75th vs <75th percentile) | Exposure | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FSRP Score | Age | Sex | Current Smoking | Diabetes | Hypertension | Prevalent CVD | ||||||||
| OR (96% CI) | P-value | OR (96% CI) | P-value | OR (96% CI) | P-value | OR (96% CI) | P-value | OR (96% CI) | P-value | OR (96% CI) | P-value | OR (96% CI) | P-value | |
| FAS - % Perseverations | 0.99 (0.95–1.03) | 0.65 | 1.04 (1.03–1.05) | <0.0001 | 0.82 (0.65–1.03) | 0.09 | 0.74 (0.53–1.04) | 0.08 | 0.75 (0.44–1.28) | 0.30 | 0.90 (0.69–1.18) | 0.46 | 0.51 (0.28–0.93) | 0.03 |
| FAS - % Total Errors | 1.01 (0.97–1.05) | 0.73 | 1.04 (1.02–1.05) | <0.0001 | 0.70 (0.55–0.89) | 0.003 | 1.29 (0.95–1.76) | 0.11 | 0.72 (0.42–1.23) | 0.22 | 1.01 (0.77–1.32)* | 0.93 | 0.79 (0.46–1.36) | 0.40 |
| Animals - % Perseverations | 1.00 (0.96–1.04) | 0.99 | 1.03 (1.01–1.04)* | 0.0003 | 1.27 (1.01–1.60) | 0.045 | 1.08 (0.79–1.47) | 0.64 | 0.62 (0.36–1.09) | 0.10 | 0.98 (0.75–1.29) | 0.89 | 1.48 (0.90–2.44) | 0.12 |
| Animals - % Total Errors | 0.98 (0.94–1.03) | 0.41 | 1.03 (1.02–1.05)* | <0.0001 | 1.23 (0.97–1.55) | 0.09 | 1.07 (0.78–1.47) | 0.66 | 0.57 (0.32–1.02) | 0.06 | 0.90 (0.69–1.19) | 0.47 | 1.46 (0.89–2.41) | 0.13 |
| Trails B - Total Errors | 1.05 (1.00–1.09) | 0.04 | 1.04 (1.03–1.05)** | <0.0001 | 0.97 (0.79–1.19) | 0.76 | 0.97 (0.73–1.28) | 0.82 | 1.18 (0.75–1.86) | 0.48 | 1.05 (0.83–1.34) | 0.68 | 1.14 (0.70–1.84) | 0.60 |
| Trails B - No. of Penlifts | 1.04 (1.00–1.09) | 0.05 | 1.06 (1.05–1.07) | <0.0001 | 1.06 (0.85–1.32) | 0.64 | 0.99 (0.73–1.34) | 0.95 | 1.23 (0.76–1.96) | 0.40 | 1.23 (0.96–1.57) | 0.11 | 0.94 (0.57–1.54) | 0.80 |
| Trails B - Early Start (Y vs. N) | 0.93 (0.84–1.01) | 0.09 | 1.05 (1.02–1.07) | 0.0001 | 1.05 (0.70–1.57) | 0.82 | 1.14 (0.66–1.98) | 0.64 | 0.57 (0.20–1.62) | 0.29 | 1.04 (0.66–1.62) | 0.88 | 0.72 (0.28–1.88) | 0.51 |
| DS-B - Capacity Score† | 1.05 (1.00–1.09) | 0.03 | 1.01 (0.99–1.02) | 0.70 | 0.93 (0.75–1.16) | 0.32 | 0.96 (0.71–1.29) | 0.77 | 1.23 (0.76–1.98) | 0.41 | 1.03 (0.80–1.33) | 0.82 | 1.09 (0.66–1.80) | 0.74 |
| DS-B - % Total Errors | 1.05 (1.01–1.10) | 0.02 | 1.00 (0.99–1.02) | 0.62 | 0.84 (0.66–1.07) | 0.15 | 1.07 (0.78–1.48) | 0.66 | 1.28 (0.76–2.14) | 0.35 | 1.03 (0.78–1.35) | 0.86 | 1.22 (0.72–2.08) | 0.46 |
| DS-B - % Sequencing Errors | 1.02 (0.98–1.06) | 0.35 | 1.00 (0.98–1.01) | 0.50 | 0.85 (0.68–1.05) | 0.13 | 1.07 (0.80–1.42) | 0.67 | 0.69 (0.41–1.17) | 0.17 | 1.08 (0.84–1.39) | 0.57 | 0.90 (0.54–1.51) | 0.70 |
Abbreviations: FSRP = Framingham Stroke Risk Profile; CVD = cardiovascular disease; OR = odds ratio; CI=confidence interval, DS-B = Digit Span Backwards
All models are adjusted for age, sex, education group (<high school degree, high school degree, college degree, >college degree), and time between risk factor measurement and neuropsychological testing.
†
Difference between DS-B total and error response score
*
Interaction with APOE4 genotype p<0.05
**
Interaction with APOE4 genotype p<0.05