. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2014 Jan-Mar;28(1):16–22. doi: 10.1097/WAD.0b013e3182a715bc

Table 4a.

Statistically Significant Interactions between ApoE4 and Midlife Cardiovascular Risk Factor Exposure on Traditional NP Outcome Measures (P-value<0.05)

Continuous Outcomes	Exposure	ApoE4− (N=1359)		ApoE4+ (N=364)		P-value for Interaction
Continuous Outcomes	Exposure	Beta (SE)	P-value	Beta (SE)	P-value	P-value for Interaction
FAS – No. total responses	Hypertension	0.10 (0.74)	0.89	−3.2 (1.4)	0.03	0.04
Animals – No. correct responses	Age	−0.20 (0.01)	<0.0001	−0.26 (0.03)	<0.0001	0.03
Animals – No. correct responses	Hypertension	−0.25 (0.29)	0.39	1.2 (0.58)	0.04	0.03
Trails B-A – Time to completion^†	Prevalent CVD	−0.10 (0.03)	0.003	0.07 (0.06)	0.21	0.01

Abbreviations: OR = odds ratio; CI=confidence interval; SE=standard error; ApoE4− = apolipoprotein ε4 negative group; ApoE4+ = apolipoprotein ε4 positive group;

All models are adjusted for age, sex, education group (<high school degree, high school degree, college degree, >college degree), and time between risk factor measurement and neuropsychological testing.

^†

Log transformed