. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2014 Jan-Mar;28(1):16–22. doi: 10.1097/WAD.0b013e3182a715bc

Table 4b.

Statistically Significant Interactions between ApoE4 and Midlife Cardiovascular Risk Factors on Error Response NP Outcome Measures (P-value<0.05)

Categorical Outcomes (≥75^th vs <75^th percentile)	Exposure	ApoE4− (N=1359)		ApoE4+ (N=364)		P-value for Interaction
Categorical Outcomes (≥75^th vs <75^th percentile)	Exposure	OR (95% CI)	P-value	OR (95% CI)	P-value	P-value for Interaction
FAS - % Total errors	Hypertension	0.86 (0.64–1.15)	0.30	1.68 (0.93–3.03)	0.08	0.04
Animals - % Perseverations	Age	1.02 (1.00–1.03)	0.03	1.06 (1.03–1.10)	0.0002	0.01
Animals - % Total Errors	Age	1.02 (1.01–1.04)	0.004	1.07 (1.03–1.10)	<0.0001	0.01
Trails B - Total Errors	Age	1.05 (1.03–1.06)	<0.0001	1.01 (0.98–1.03)	0.63	0.006

Abbreviations: OR = odds ratio; CI=confidence interval; ApoE4− = apolipoprotein ε4 negative group; ApoE4+ = apolipoprotein ε4 positive group;

All models are adjusted for age, sex, education group (<high school degree, high school degree, college degree, >college degree), and time between risk factor measurement and neuropsychological testing.