Table 2. Functional annotation clustering of putative SREBP1 targets with a different temporal expression profile.

PHASE	n	Functional cluster	GO term	P-value
ZT13-ZT19	42	cholesterol metabolism	GO:0008203	0.01
		amino acid binding	GO:0016597	2.00E-03
		response to starvation	GO:0042594	1.90E-03
		response to hormones	GO:0009725	6.10E-03
		glycerolipid metabolism	GO:0046486	3.10E-03
		cell migration	GO:0016477	0.017
ZT19-ZT28.4	68	sterol metabolism	GO:0016126	1.60E-09
		magnesium ion binding	GO:0000287	1.00E-03
		coenzyme biosynthesis	GO:0006732	0.019
		nucleotide binding	GO:0032555	0.041
		endoplasmic reticulum	GO:0005783	0.041
ZT4.4-ZT13	39	mitochondria	GO:0005739	3.20E-03
		regulation of apoptosis	GO:0042981	6.70E-03
		regulation of myeloid cell differentiation	GO:0045637	2.30E-03

Enriched GO categories were identified in three distinct sets of rhythmic SREBP1 target genes (P<0.05), based of their phase of expression. To define the three intervals of time we calculated the shortest time range containing the phases of at least 50% of the genes belonging to clusters A1, A2 or A3. For each set, the total number of genes is indicated and the number of genes with annotation is indicated in parentheses. For each functional cluster, only the most significant associated GO term is shown in the table, with the corresponding Modified Fisher Exact P-value.