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Drug Suitability Profile of AND-302.
| Assay | AND-302 | |
|---|---|---|
| Aqueous Solubility | pH 1.2 | 7.6 mg/mL |
| pH 7.4 | 11.1 mg/mL | |
| pH 9.2 | 9.2 mg/mL | |
|
| ||
| Caco-2 cell permeability (Papp × 10−6 cm/s) | 50 (high) | |
|
| ||
| Liver Microsome Stability (% remaining after 60 min) | Rat: 100% | |
| Mouse: 89% | ||
| Human: 73% | ||
|
| ||
| Plasma Protein Binding | -Human | 57% |
| -Mouse | 39% | |
|
| ||
| Cytochrome P450 Inhibition (IC50) |
3A4 | 74 μM |
| 1A2 | >120 μM | |
| 2C9 | >120 μM | |
| 2D6 | >120 μM | |
| 2C19 | 96 μM | |
|
| ||
| hERG (IC50) | >30 μM | |
