Table 1.
Characteristics of UDS Participants With aMCI and AD at Index Visit, 2005-2012
| Characteristic at Index Visita | aMCI (n=2,268) | AD (n=1,506) |
|---|---|---|
| Age in years, mean (SD) | 76.0 (8.4) | 78.2 (6.7) |
| Primary reported race/ethnicity (%) | ||
| Non-Hispanic White | 81.8 | 82.8 |
| Non-Hispanic Black | 10.4 | 9.3 |
| Other Non-Hispanic | 2.3 | 2.6 |
| Hispanic | 5.6 | 5.3 |
| Male sex (%) | 51.1 | 48.9 |
| Education (%) | ||
| ≤12 years | 23.8 | 36.9 |
| 13-16 years | 43.9 | 38.1 |
| ≥17+ years | 32.3 | 25.0 |
| ≥1 Comorbidity (%)b | 16.0 | 12.9 |
| Hypercholesterolemia (%) | 52.3 | 53.5 |
| Hypertension (%) | 51.6 | 50.3 |
| Depression (GDS score ≥6) (%) | 10.8 | 9.5 |
| Years since cognitive decline began (%) | 58.4 | |
| <5 years | 69.0 | 34.7 |
| 5 to 9 years | 24.5 | 6.9 |
| ≥ 10 years | 6.5 | |
| CDR-SB, mean (SD) | 1.3 (0.9) | 4.6 (1.7) |
| Index visit BMI (iBMI) (%) | ||
| Low iBMI (<20.0 kg/m2) | 3.8 | 5.8 |
| Middle iBMI (20 to <27.5 kg/m2) | 59.7 | 56.6 |
| High iBMI (≥27.5 kg/m2)) | 36.6 | 34.5 |
| One-year WC (%) | ||
| Weight loss of >4% | 18.1 | 20.9 |
| Weight gain of >4% | 12.9 | 18.2 |
| No change (≤ 4% weight loss or gain) | 69.1 | 61.0 |
| ≥1 APOE ε4 allele (%) | 44.6 | 61.8 |
Abbreviations: UDS, Uniform Data Set; aMCI; amnestic MCI; AD; Alzheimer’s Disease; SD; standard deviation; iBMI, index visit BMI; GDS; Geriatric Depression Scale; CDR-SB; Clinical Dementia Rating Sum of Boxes; WC, weight change; APOE, Apolipoprotein E
Missing data (aMCI/AD): age (0.0%/0.0%), race/ethnicity (0.1%/0.3%), sex (0.0%/0.0%), education (0.2%/0.2%), comorbidities (0.0%/0.0%), hypercholesterolemia (0.0%/0.0%), hypertension (0.0%/0.0%), depression (1.5%/2.7%), years since cognitive decline began (7.5%/0.9%), CDR-SB (0.0%/0.0%), iBMI (0.0%/0.0%), one-year WC (0.0%/0.0%), APOE (33.3%/21.2%).
Participants have one or more of the following comorbidities: Diabetes, heart failure, cardiac arrest, or cerebrovascular disease (TIA and/or stroke).