. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: Alzheimer Dis Assoc Disord. 2014 Jan-Mar;28(1):36–43. doi: 10.1097/WAD.0000000000000005

Table 2.

Baseline CDR-SB Differences and Differences in Mean CDR-SB Annual Change by BMI at Index Visit, UDS Participants, 2005-2012

	aMCI				AD
	Unadjusted iBMI Model		Adjusted iBMI Model^b		Unadjusted iBMI Model		Adjusted iBMI Model^b
Model Term	Estimate	95% CI (P value)	Estimate	95% CI (P Value)	Estimate	95% CI (P Value)	Estimate	95% CI (P Value)
Baseline differences in mean CDR-SB
Low iBMI^a	0.17	−0.05, 0.40 (0.13)	0.17	−0.05, 0.39 (0.12)	−0.01	−0.41, 0.38 (0.94)	−0.14	−0.57, 0.29 (0.52)
Moderate iBMI^a		Ref		Ref		Ref		Ref
High iBMI^a	0.11	0.02, 0.19 (0.02)	0.13	0.04, 0.22 (0.003)	0.18	0.01, 0.34 (0.03)	0.17	0.02, 0.32 (0.03)
Differences in mean CDR-SB change per year
Low iBMI^a	0.22	−0.04, 0.49 (0.09)	0.22	−0.04, 0.49 (0.09)	0.25	−0.14, 0.64 (0.21)	0.26	−0.13, 0.66 (0.19)
Moderate iBMI^a		Ref		Ref		Ref		Ref
High iBMI^a	−0.18	−0.30, −0.07 (0.001)	−0.20	−0.32, −0.08 (0.001)	−0.17	−0.36, 0.02 (0.08)	−0.16	−0.34, 0.02 (0.09)

Abbreviations: CDR-SB, Clinical Dementia Rating Sum of Boxes; UDS, Uniform Data Set; iBMI, body mass index at index visit; aMCI, amnestic MCI; AD, Alzheimer's Disease; Ref, reference group

Low iBMI is <20 kg/m², Moderate iBMI is 20 to ≥27.5 kg/m², High iBMI is ≥27.5 kg/m²

Adjusting for age at index visit, years of education, sex, race/ethnicity, comorbidities, hypertension, hypercholesterolemia, years since cognitive decline began, and depression