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BL153 prevented HFD-induced cardiac apoptosis via activation of the mitochondrial cell death pathway. The expression of C-caspase-8 (cleaved-caspase-8), Bax, Bcl-2, and AIF in the heart was detected by Western blot assay and quantified by densitometric analysis. Data were presented as mean ± SD (n = 5). a P < 0.05 versus control. b P < 0.05 versus HFD group.
