Table 1.
The effects of BL153 on cardiac function in HFD feeding mice.
| Control | HFD | HFD + 2.5 mg/kg | HFD + 5.0 mg/kg | HFD + 10 mg/kg | |
|---|---|---|---|---|---|
| IVS; d (mm) | 0.72 ± 0.03 | 0.71 ± 0.03 | 0.69 ± 0.02 | 0.70 ± 0.03 | 0.70 ± 0.0232 |
| LVID; d (mm) | 3.26 ± 0.18 | 3.61 ± 0.25 | 3.61 ± 0.17 | 3.68 ± 0.21 | 3.72 ± 0.23 |
| LVPW; d (mm) | 0.80 ± 0.10 | 0.85 ± 0.08 | 0.99 ± 0.08 | 0.89 ± 0.18 | 0.96 ± 0.10 |
| IVS; s (mm) | 1.10 ± 0.02 | 1.16 ± 0.15 | 1.03 ± 0.12 | 1.13 ± 0.17 | 1.19 ± 0.10 |
| LVID; s (mm) | 1.37 ± 0.23 | 1.72 ± 0.36 | 1.77 ± 0.35 | 1.82 ± 0.25 | 1.60 ± 0.19 |
| LVPW; s (mm) | 0.50 ± 0.24 | 1.48 ± 0.34 | 1.74 ± 0.25 | 1.55 ± 0.26 | 1.79 ± 0.20 |
| LV vol; d (μL) | 43.16 ± 5.55 | 55.49 ± 9.08 | 55.05 ± 5.90 | 57.83 ± 8.07 | 59.40 ± 8.56 |
| LV vol; s (μL) | 4.98 ± 2.04 | 9.40 ± 4.69 | 10.06 ± 4.73 | 10.54 ± 4.03 | 7.60 ± 2.29 |
| %EF | 88.76 ± 3.29 | 82.59 ± 10.14 | 81.71 ± 8.58 | 82.18 ± 4.45 | 87.44 ± 3.15 |
| %FS | 58.24 ± 4.59 | 52.25 ± 11.21 | 50.99 ± 10.22 | 50.80 ± 4.69 | 57.13 ± 4.15 |
| LV mass (mg) | 79.02 ± 3.31 | 97.10 ± 15.86 | 106.85 ± 13.03 | 101.68 ± 18.27 | 110.94 ± 18.34 |
| HR (beats/min) | 697.93 ± 53.40 | 677.98 ± 50.60 | 689.18 ± 34.90 | 675.86 ± 36.11 | 667.95 ± 27.90 |
| Systolic BP (mmHg) | 110.92 ± 5.13 | 113.09 ± 3.71 | 97.90 ± 11.34 | 98.79 ± 10.41 | 109.39 ± 5.48 |
| Diastolic BP (mmHg) | 79.69 ± 6.99 | 77.30 ± 5.65 | 69.75 ± 10.10 | 70.68 ± 10.27 | 79.34 ± 4.75 |
| Mean BP (mmHg) | 89.76 ± 6.35 | 88.92 ± 3.82 | 78.79 ± 10.46 | 79.73 ± 10.30 | 89.03 ± 4.84 |
Notes. IVS: interventricular septum; LVID; d: left ventricular end diastolic diameter; LVID; s: left ventricular end systolic diameter; LVPW: left ventricular posterior wall; EF: ejection fraction; FS: fractional shortening; LV vol; s: left ventricular end systolic volume; LV vol; d: left ventricular end diastolic volume; LV mass: left ventricular mass. HR: heart rate; BP: blood pressure. Data were presented as means ± SEM (n = 5).