TABLE 4.
Interactions (hydrogen bonds (HB), hydrophobic (PHOB), and cation-π) formed between arginine and residues of the binding site of either AdiC or Can1 in the sandwich configuration (see “Results”)
| Arginine ligand | AdiC (PDB code 3L1L) (8) |
Can1 three-dimensional model |
||
|---|---|---|---|---|
| Backbone | Side chain | Backbone | Side chain | |
| Backbone | ||||
| NH3+ | HB Ile-23 (TM1) | HB Thr-101 (TM1) | ||
| HB Trp-202 (TM6) | HB Phe-295 (TM6) | |||
| HB Ile-205 (TM6) | HB Gln-298 (TM6) | |||
| COO− | HB Gly-27 (TM1) | HB Ser-26 (TM1) | HB Gly-103 (TM1) | HB Thr-104 (TM1) |
| HB Thr-104 (TM1) | ||||
| Side chain | ||||
| CH2 | PHOB Trp-202 (TM6) | PHOB Phe-295 (TM6) | ||
| Guanidinium+ | HB Ala-96 (TM3) | HB Asn-101 (TM3) | HB Ser-176 (TM3) | |
| HB Cys-97 CO (TM3) | HB Ser-357 (TM10) | HB Thr-180 (TM3) | ||
| Cation-π Trp-293 (TM8) | HB Glu-301 (TM6) | |||
| HB Thr-456 (TM10) | ||||
| Cation-π Trp-177 (TM3) | ||||