Figure 1.

Radiotherapy could induce various types of damage in both hard and soft tissues, and cause a considerable number of diseases and dysfunctions, such as osteoradionecrosis (ORN), radiation caries, changes in peri-implant flora, oral mucosa disease, periodontal disease, periodontium disease, salivary glands disease, dysfunction of muscles and joints, and imbalance of nutritional status. Some strategies, like the use of hyperbaric oxygen (HBO), bone morphogenetic protein (BMP), and osteogenic growth peptide (OGP), have been proposed to improve the implant survival rate after radiotherapy.