Fig. 1.

Representative waveforms demonstrating differential effects of clozapine alone (0.33 mg/kg, i.p.) vs. the combination of clozapine (0.33 mg/kg, i.p.) and dronabinol (10 mg/kg, i.p.) on P20-N40 gating in DBA/2 mice. Waveforms on the left side represent pre-drug (i.e. baseline) responses to the first (S1) and second (S2) stimuli. Waveforms on the right side represent post-drug responses to the first and second stimuli. Burst response artifacts represent the auditory stimuli, and tic marks denote the P20-N40 auditory evoked potentials. In these representative examples, injection of clozapine alone reduced S2/S1 ratio relative to baseline; however, co-injection of clozapine and dronabinol did not affect S2/S1 ratio relative to baseline.