Table 1.
Effect of dried pulp of Aloe succotrina leaves on body weight of HFD-induced hyperlipidemic rats.
| Group number |
Treatment (p.o.) |
Dose (kg−1) |
Number of animals |
Body weight (g) | ||||
|---|---|---|---|---|---|---|---|---|
| Week 0 | Week 1 | Week 2 | Week 3 | Week 4 | ||||
| 1 | Vehicle (1% w/v CMC) | 10 mL | 6 | 83.16 ± 3.98 | 87.66 ± 4.09 | 95.5 ± 3.77 | 103.33 ± 4.82 | 104.33 ± 4.78 |
| 2 | Vehicle (1% w/v CMC) + HFD | 10 mL | 6 | 82.33 ± 2.96 | 102.16 ± 3.19a | 112.66 ± 4.73c | 129.66 ± 5.90c | 136.00 ± 5.75c |
| 3 | Atorvastatin + HFD | 10 mg | 3 | 83.00 ± 4.44 | 98.16 ± 5.16 | 118.16 ± 8.37 | 124.00 ± 8.09 | 133.33 ± 11.86 |
| 4 | Aloe succotrina + HFD | 100 mg | 5 | 79.16 ± 3.92 | 101.83 ± 5.134 | 124.5 ± 5.74 | 106.66 ± 5.48 | 115.8 ± 16.33 |
| 5 | Aloe succotrina + HFD | 200 mg | 5 | 81.83 ± 5.13 | 104.00 ± 7.17 | 129.83 ± 8.25 | 138.83 ± 6.98 | 150.6 ± 7.36 |
In each group; values are in Mean ± SEM; data were analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test.
F (4, 25) = 21.29; P < 0.0001 (for HFD treated control from week 0 to week 4).
F (4, 25) = 1.636; P < 0.1964 (comparison among various groups at week 1).
F (4, 25) = 4.207; P < 0.0097 (comparison among various groups at week 2).
F (4, 25) = 5.585; P < 0.0024 (comparison among various groups at week 3).
F (4, 20) = 7.901; P < 0.0005 (comparison among various groups at week 4).
a P < 0.05 and c P < 0.001 as compared to HFD treated control (week 0).