Table 3.

Effect of dried pulp of Aloe succotrina leaves on serum lipid levels in HFD-induced hyperlipidemic rats.

Group number	Treatment (p.o.)	Dose (kg−1)	Lipid levels (mg/dL)
			TC	TG	HDL-c	VLDL	LDL-c	AI (TG/HDL)
1	Vehicle (1% w/v CMC)  (n = 6)	10 mL	78.24 ± 4.08	19.55 ± 5.04	37.18 ± 0.45	3.91 ± 1.01	36.99 ± 4.64	0.28 ± 0.07
2	Vehicle (1% w/v CMC) + HFD (n = 6)	10 mL	315.42 ± 27.17###	108.04 ± 11.67###	17.38 ± 3.97###	21.60 ± 2.34###	276.40 ± 26.38###	10.57 ± 3.86#
3	Atorvastatin + HFD  (n = 3)	10 mg	156.06 ± 20.65c	28.42 ± 6.65b	50.37 ± 3.67c	5.68 ± 1.33b	100.00 ± 20.36c	0.55 ± 0.09a
4	Aloe succotrina + HFD  (n = 5)	100 mg	231.32 ± 22.00a	94.90 ± 21.38	33.94 ± 3.30b	18.98 ± 4.28	178.45 ± 22.40b	2.84 ± 0.63
5	Aloe succotrina + HFD  (n = 5)	200 mg	181.30 ± 12.26c	48.34 ± 9.66a	47.65 ± 1.24c	9.67 ± 1.93a	123.98 ± 11.70c	1.02 ± 0.22a

Values are in Mean ± SEM; data was analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test. TC—total cholesterol; TG—triglycerides; HDL-c—high density lipoprotein-cholesterol; LDL-c—low density lipoprotein-cholesterol; VLDL—very low density lipoprotein- cholesterol; AI—atherogenic index.

F (4, 20) = 25.856; P < 0.0001 (for total cholesterol).

F (4, 20) = 10.308; P < 0.0001 (for triglycerides).

F (4, 20) = 21.007; P < 0.0001 (for HDL-c).

F (4, 20) = 10.297; P < 0.0001 (for VLDL).

F (4, 20) = 27.085; P < 0.0001 (for LDL-c).

F (4, 20) = 4.623; P < 0.0083 (for AI).

^# P < 0.05 and ^### P < 0.001 as compared to vehicle treated control; ^a P < 0.05, ^b P < 0.01, and ^c P < 0.001 as compared to HFD treated control.