Table 4.
Effect of dried pulp of Aloe succotrina leaves on liver HMG/mevalonate ratio, malondialdehyde (MDA), and reduced glutathione (GSH) levels of HFD-induced hyperlipidemic rats.
| Group number | Treatment (p.o.) | Dose (kg−1) | Number of animals | HMG/mevalonate ratio | MDA levels (nmol/mg tissue) | GSH levels (μmol/mg tissue) |
|---|---|---|---|---|---|---|
| 1 | Vehicle (1% w/v CMC) | 10 mL | 6 | 0.59 ± 0.23 | 52.60 ± 10.49 | 735.21 ± 57.31 |
| 2 | Vehicle (1% w/v CMC) + HFD | 10 mL | 6 | 0.37 ± 0.13 | 179.74 ± 23.77## | 297.62 ± 24.81### |
| 3 | Atorvastatin + HFD | 10 mg | 3 | 3.29 ± 0.37c | 13.43 ± 4.65c | 665.84 ± 24.34c |
| 4 | Aloe succotrina + HFD | 100 mg | 5 | 0.81 ± 0.13 | 78.56 ± 27.66b | 303.84 ± 31.85 |
| 5 | Aloe succotrina + HFD | 200 mg | 5 | 1.68 ± 0.34b | 52.72 ± 12.32c | 617.86 ± 26.35c |
Values are in Mean ± SEM; data was analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test.
F (4, 20) = 14.402; P < 0.0001 (for HMG/mevalonate ratio).
F (4, 20) = 10.117; P < 0.0001 (for MDA levels).
F (4, 20) = 25.390; P < 0.0001 (for reduced glutathione levels).
## P < 0.01 and ### P < 0.001 as compared to vehicle treated control; b P < 0.05 and c P < 0.001 as compared to HFD treated control.