Table 7.
Effect of the dried pulp of Aloe succotrina leaves on serum lipid levels in fructose-induced hyperlipidemic rats.
| Group number |
Treatment (p.o.) |
Dose (kg−1) |
Lipid Levels (mg/dL) | |||||
|---|---|---|---|---|---|---|---|---|
| TC | TG | HDL-c | VLDL | LDL-c | AI (TG/HDL) |
|||
| 1 | Vehicle (1% w/v CMC) | 10 mL | 67.09 ± 2.74 | 39.47 ± 1.75 | 37.26 ± 1.83 | 7.93 ± 0.37 | 21.83 ± 4.54 | 1.07 ± 0.06 |
| 2 | Vehicle (1% w/v CMC) + fructose (25% w/v) | 10 mL | 85.56 ± 4.37# | 67.10 ± 12.69# | 17.36 ± 1.49# | 13.42 ± 2.54# | 54.80 ± 6.03## | 3.93 ± 0.74### |
| 3 | Atorvastatin + fructose (25% w/v) | 10 mg | 64.32 ± 4.09a | 22.59 ± 2.14c | 41.72 ± 6.06b | 4.52 ± 0.43c | 18.09 ± 4.89b | 0.60 ± 0.10c |
| 4 | Aloe succotrina + fructose (25% w/v) | 100 mg | 71.97 ± 6.12 | 33.22 ± 3.98b | 42.33 ± 5.48 | 6.64 ± 0.80b | 38.53 ± 6.94 | 1.42 ± 0.32c |
| 5 | Aloe succotrina + fructose (25% w/v) | 200 mg | 66.15 ± 2.16a | 24.74 ± 2.44c | 26.80 ± 4.71b | 4.95 ± 0.49c | 18.87 ± 5.27b | 0.62 ± 0.09c |
(n = 5) in each group; values are in Mean ± SEM; data was analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test.
TC—total cholesterol; TG—triglycerides; HDL-c—high density lipoprotein- cholesterol.
LDL-c—low density lipoprotein- cholesterol; VLDL—very low density lipoprotein- cholesterol; AI—atherogenic index.
F (4, 21) = 4.344; P < 0.0109 (for total cholesterol); F (4, 21) = 8.425; P < 0.0004 (for triglycerides); F (4, 21) = 6.170; P < 0.0021 (for HDL-c); F (4, 21) = 8.414; P < 0.0004 (for VLDL); F (4, 21) = 8.118; P < 0.0005 (for LDL-c); F (4, 21) =14.361; P < 0.0001 (for AI).
# P < 0.05, ## P < 0.01, and ### P < 0.001 as compared to vehicle treated control; a P < 0.05, b P < 0.01, and c P < 0.001 as compared to fructose treated control.