Table 8.
Effect of dried pulp of Aloe succotrina leaves on liver HMG/mevalonate ratio, MDA, and reduced glutathione (GSH) levels of fructose-induced hyperlipidemic rats.
| Group number |
Treatment (p.o.) |
Dose (kg−1) |
HMG/mevalonate ratio | MDA levels (nmol/mg tissue) | GSH levels (μmol/mg tissue) |
|---|---|---|---|---|---|
| 1 | Vehicle (1% w/v CMC) | 10 mL | 3.44 ± 1.22 | 7.64 ± 1.56 | 524.55 ± 35.89 |
| 2 | Vehicle (1% w/v CMC) + fructose (25% w/v) | 10 mL | 1.98 ± 0.36 | 49.02 ± 0.92### | 317.20 ± 19.40### |
| 3 | Atorvastatin + fructose (25% w/v) | 10 mg | 6.17 ± 0.93a | 6.92 ± 0.69c | 445.74 ± 19.57a |
| 4 | Aloe succotrina + fructose (25% w/v) | 100 mg | 3.75 ± 0.78 | 31.66 ± 8.33a | 324.04 ± 13.31 |
| 5 | Aloe succotrina + fructose (25% w/v) | 200 mg | 5.66 ± 0.67a | 8.85 ± 2.05c | 428.13 ± 34.29a |
(n = 5) in each group; values are in Mean ± SEM; data was analyzed by one-way ANOVA followed by Tukey-Kramer multiple comparison test.
F (4, 21) = 4.140; P < 0.0001 (for HMG/mevalonate ratio).
F (4, 21) = 7.607; P < 0.0007 (for MDA levels).
F (4, 21) = 11.289; P < 0.0001 (for reduced glutathione).
### P < 0.001 as compared to vehicle treated control.
a P < 0.05, b P < 0.05, and c P < 0.001 as compared to fructose treated control.