Figure 1.

Anti-IL-17A mAb and IL-1Ra decreased the secretion of IL-17A in silica-induced Th response in vitro. (a) The secretion of IL-17A in supernatant of the macrophage-lymphocyte cocultured system was assayed by ELISA. ((b) and (c)) The expressions of IL-17A and ROR-γt in lymphocytes were assayed by realtime PCR. The concentration of IL-1Ra is 15 μg/mL and the concentration of anti-IL-17A mAb is 20 μg/mL. Data were presented as mean ± SEM (n = 5). #: P < 0.05, significantly different compared with the PBS group. Δ: P < 0.05, significantly different compared with the silica group.