Fig. 2. L5 spinal nerve injury in rats differentially alters MrgC mRNA levels in injured and uninjured DRGs.
(A) The MrgC mRNA levels in L4 DRGs did not differ significantly between the ipsilateral and contralateral sides of rats that underwent sham surgery (n=5). MrgC mRNA level was significantly increased in the ipsilateral L4 DRG on day 14 (n=5) and day 30 (n=5) post-SNL, as compared to that on the contralateral side. (B) However, MrgC mRNA level was significantly decreased in the ipsilateral L5 DRG for at least 120 days post-SNL (n=4). Unpaired t-test. Data are expressed as mean + SEM.