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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: J Mol Biol. 2013 Dec 12;426(6):1265–1284. doi: 10.1016/j.jmb.2013.12.005

Figure 6. TRIM19/PML isoforms.

Figure 6

TRIM19 isoforms, depicted here as PML I – PML VII are shown according to the nomenclature described by Jensen et al 162. All TRIM19/PML isoforms retain the first 3 exons which encode for the RBCC motif: RING (R), B-box (B1 and B2), and the coiled-coil domain (CC). The isoforms I to VII PMLI to PMLVII differ by alternative splicing of exons 7 to 9. The cytoplasmic form of TRIM19 (cPML) is the result of alternative splicing of exons 4–6. Adapted from Nisole et al. 135.