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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Apoptosis. 2014 Mar;19(3):451–466. doi: 10.1007/s10495-013-0942-3

Fig. 4. Cdk inhibitors induce apoptosis in Caco-2 cells.

Fig. 4

(A) Caco-2 cells were treated with DMSO, 5 M AZD5438, 5 M NU6140 and 2 M CPT during proliferation for the indicated time periods. Cell lysates were analyzed for active caspase-3 using specific antibody. Actin was used as an internal loading control. (B) Caco-2 cells were treated with DMSO, 5 M AZD5438, 5 M NU6140 and 2 M CPT during proliferation for 48h. DNA fragmentation was measured by ELISA. Values expressed are mean SE, n=3. *significantly different compared to DMSO treated cells (P<0.05).