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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Apoptosis. 2014 Mar;19(3):451–466. doi: 10.1007/s10495-013-0942-3

Fig. 8. Cdk2 inhibitor NU6140 rescues non-proliferating IEC-6 cells from CPT+TNF-induced apoptosis.

Fig. 8

(A) Confluent serum-starved IEC-6 cells were treated with indicated doses of NU6140 for 1h followed by CPT+TNF- treatment for 3h. Cell lysates were analyzed by western blot for phospho-p53 Ser15, total-p53, and p21Cip1 using specific antibodies. Actin was used as a loading control. (B) DNA fragmentation was measured by ELISA. Values expressed are mean SE, n=3. *significantly different compared to DMSO treated cells (P<0.05), **significantly different compared to CPT+TNF treated group (P<0.05).