Figure 2.

Social recognition memory and locomotor activity evaluation. The social recognition test (SR) in the wild type (WT-SAL) and 2xTg-AD animals (AD-SAL; AD-MSC and AD-MSC-VEGF), as evaluated by the sniffing duration (seconds) to the same intruder (session 1–4) and to a different intruder (5th session) at 6 months (A), 9 months (B) and 12 months of age (C). Repeated measures ANOVA followed by post hoc Bonferroni’s test (mean ± standard error, * P < 0.05; ** P < 0.01; *** P < 0.001, n = 10 per group). Differences between the first four trials are indicated in the trial number 1, and differences between the 4th and 5th trials are indicated in trial number 5. Color lines and point markers connect the mean values for the groups in each session (SAL-WT in blue; AD-MSC-VEGF in green; AD-MSC in yellow; AD-SAL in red). In (D), the general locomotor activity of the WT and AD mice groups in the OF test for each age (6, 9 and 12 months), as evaluated by the total locomotion frequency of the quadrants traversed. There were no statistical differences between groups.