Table 2.
Cox regression unadjusted and adjusted hazard ratios for clinical factors predicting for the risk of receipt of sAST.
| Clinical factor | Number of men | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| HR (95% CI) | P value | AHR (95% CI) | P value | ||
| Initial treatment | |||||
| RT only | 34 | 1.47 (0.74, 2.93) | 0.27 | 2.30 (1.02, 5.18) | 0.05 |
| RT + AST | 15 | 1.00 (Ref) | — | 1.00 (Ref) | — |
| ACE-27 comorbidity score | |||||
| None to minimal | 39 | 1.00 (Ref) | — | 1.00 (Ref) | — |
| Moderate to severe | 10 | 1.32 (0.37, 4.72) | 0.67 | 2.67 (0.60, 11.97) | 0.20 |
| Treatment × comorbidity score interaction | 49 | 0.51 (0.11, 2.42) | 0.39 | 0.14 (0.02, 1.05) | 0.06 |
| Age, yr | 49 | 0.96 (0.91, 1.02) | 0.17 | 0.97 (0.92, 1.04) | 0.39 |
| BMI, kg/m2 | 49 | 1.07 (1.00, 1.14) | 0.04 | 1.11 (1.04, 1.18) | 0.002 |
| 2013 NCCN risk group | |||||
| Low or intermediate risk | 30 | 1.00 (Ref) | — | 1.00 (Ref) | — |
| High risk | 19 | 1.56 (0.87, 2.82) | 0.14 | 2.01 (1.05, 3.83) | 0.03 |
| Percent positive biopsies | 49 | 1.00 (0.99, 1.01) | 0.68 |
1.01 (0.99, 1.02) | 0.35 |
Abbreviations: BMI: body mass index, RT: radiation therapy, AST: androgen suppression therapy, sAST: salvage androgen suppression therapy, ACE: Adult Comorbidity Evaluation, IQR: interquartile range, HR: hazard ratio, and AHR: adjusted hazard ratio.