. 2013 Oct 31;93(4):609–616. doi: 10.1007/s00277-013-1920-0

Table 1.

The diagnostic main clinical–hematologic characteristics of the 105 individuals included in the present study grouped according to diagnosis

Characteristics	Donors (n = 23)	SP (n = 13)	PV (n = 22)	ET (n = 38)	PMF (n = 9)
Age, median (years) (range)	45 (26–61)	59 (27–90)	65 (52–88)	63 (35–80)	62 (38–81)	75 (70–80)	68 (47–83)
Gender, male/female	16/7	13/0	17/5	4/5	20/29	2/4	3/5
Hb (g/dl), median (range)	15 (11.5–16.9)	17 (16–18.2)	18 (17.6–20.2)	12.5 (11.6–14)	15 (12–19)	9.6 (8.9–10)	15.4 (13.8–17.3)
WBC (1 × 10⁹/l), median (range)	6.6 (4.7–9.3)	7.1 (4.8–11.4)	10.6 (4.4–15)	8.5 (6–10)	9.9 (7.1–18)	8 (1.3–16.8)	20.6 (20–10.8)
PLTs (1 × 10⁹/l), median (range)	232 (192–349)	200.5 (91–274)	370 (75–712)	792 (631–1,420)	718 (256–1,318)	364 (129–489)	555 (197–946)
Neutrophils (1 × 10⁹/l), median (range)	4.4 (1.4–7)	4.6 (1.4–7.5)	7.9 (2.7–13)	4.6 (2.8–7.6)	6 (1.4–13.5)	5.1 (1–9.4)	15.9 (8.4–19.5)
JAK2WT copy numbers (1 × 10³), median (range)	7.7 (1.2–38.5)	8.7 (2.5–30.9)	6.9 (0.02–22.6)	15.6 (6.2–34.5)	6.0 (0.9–16.7)	11.2 (3.8–18.5)	3.0 (0.3–4.5)
JAK2V617F copy numbers (1 × 10³), median (range)	–	–	26.9 (0.2–203.6)	–	6.9 (0.7–52.8)	–	29.4 (1.4–78.7)
ABL1 copy number (1 × 10³), median (range)	4.6 (1.6–11.9)	5.0 (2.4–20.6)	2.9 (0.9–12.7)	7.4 (1.8–17.7)	3.8 (0.3–8.7)	8.6 (4.6–14.9)	3.3 (1.7–4.6)
B2M copy number (1 × 10⁶), median (range)^a	8.0 (2.8–10.1)	4.8 (2.5–13.0)	8.8 (2.4–17.7)	6.1 (2.4–7.9)	8.1 (2.4–17.3)	6.0	7.0 (2.3–13.4)
GUSB copy number (1 × 10³), median (range)^a	37.6 (7.4–53.2)	34.5 (3.2–58.7)	37.8 (0.2–56.7)	39.8 (8.6–71.6)	33.2 (5.8–59.1)	23.4	41.0 (19.3–93.5)

Characteristics

Donors (n = 23)

SP (n = 13)

PV (n = 22)

ET (n = 38)

PMF (n = 9)

JAK2WT/V617F (n = 0) (n = 22; 100 %)

JAK2WT/V617F (n = 9; 19.5 %) (n = 29; 80.5 %)

JAK2WT/V617F (n = 4) (n = 5)

Age, median (years)

(range)

(26–61)

(27–90)

(52–88)

(35–80)

(38–81)

(70–80)

(47–83)

Gender, male/female

16/7

13/0

17/5

4/5

20/29

2/4

3/5

Hb (g/dl),

median (range)

(11.5–16.9)

(16–18.2)

(17.6–20.2)

12.5

(11.6–14)

(12–19)

9.6

(8.9–10)

15.4

(13.8–17.3)

WBC (1 × 10⁹/l),

median (range)

6.6

(4.7–9.3)

7.1

(4.8–11.4)

10.6

(4.4–15)

8.5

(6–10)

9.9

(7.1–18)

(1.3–16.8)

20.6

(20–10.8)

PLTs (1 × 10⁹/l),

median (range)

232

(192–349)

200.5

(91–274)

370

(75–712)

792

(631–1,420)

718

(256–1,318)

364

(129–489)

555

(197–946)

Neutrophils (1 × 10⁹/l),

median (range)

4.4

(1.4–7)

4.6

(1.4–7.5)

7.9

(2.7–13)

4.6

(2.8–7.6)

(1.4–13.5)

5.1

(1–9.4)

15.9

(8.4–19.5)

JAK2WT copy numbers (1 × 10³),

median (range)

7.7

(1.2–38.5)

8.7

(2.5–30.9)

6.9

(0.02–22.6)

15.6

(6.2–34.5)

6.0

(0.9–16.7)

11.2

(3.8–18.5)

3.0

(0.3–4.5)

JAK2V617F copy numbers (1 × 10³),

median (range)

–

26.9

(0.2–203.6)

–

6.9

(0.7–52.8)

–

29.4

(1.4–78.7)

ABL1 copy number (1 × 10³),

median (range)

4.6

(1.6–11.9)

5.0

(2.4–20.6)

2.9

(0.9–12.7)

7.4

(1.8–17.7)

3.8

(0.3–8.7)

8.6

(4.6–14.9)

3.3

(1.7–4.6)

B2M copy number (1 × 10⁶),

median (range)^a

8.0

(2.8–10.1)

4.8

(2.5–13.0)

8.8

(2.4–17.7)

6.1

(2.4–7.9)

8.1

(2.4–17.3)

6.0

7.0

(2.3–13.4)

GUSB copy number (1 × 10³),

median (range)^a

37.6

(7.4–53.2)

34.5

(3.2–58.7)

37.8

(0.2–56.7)

39.8

(8.6–71.6)

33.2

(5.8–59.1)

23.4

41.0

(19.3–93.5)

^a B2M and GUSB copy numbers were detected in donor (n = 11), SP (n = 5), PV (n = 16), ET (WT n = 7; V617F n = 24), and PMF (WT n = 1; V617F n = 4) samples