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. 2014 Mar 6;9(3):e89617. doi: 10.1371/journal.pone.0089617

Figure 4. Selective antagonism of ligand-dependent cell survival.

Figure 4

NIH-3T3 cells expressing either TrkA or TrkC or IGF-1R were cultured in SFM supplemented with the indicated peptidomimetic (10 µM) with optimal (a) or suboptimal (b) concentrations of the appropriate growth factor for 72 h. Survival was measured in MTT assays, and was calculated relative to optimal growth factor-mediated survival (100%). Results shown are average + SEM, from at least three independent experiments. One-way ANOVA, p<0.05 considered significant. All “hits” shown were significant for inhibition of TrkC, only 1a and 1b “hits” were significant for inhibition of TrkA.