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. 2014 Mar 6;9(3):e89614. doi: 10.1371/journal.pone.0089614

Figure 5. Competition between P. aeruginosa and S. aureus strains in a murine model of pneumoniae.

Figure 5

Planktonic S. aureus strain Newman and P. aeruginosa clinical isolates AA2 and AA43 and reference strain PA14 were used to infect C57BL/6NCrlBR mice at a ratio of 1∶1. After 18 hours of acute infection lungs homogenates were plated on selective plates to determine S. aureus and P. aeruginosa CFU. Each circle represents the CI for a single animal in each group. A CI value equal to 1 indicates equal competition of the two species; a CI value significantly <1 indicates a competitive advantage of S. aureus that outcompetes P. aeruginosa; a CI value significantly >1 indicates a competitive advantage of P. aeruginosa that outcompetes S. aureus. Wilcoxon signed rank test of the null hypothesis that the distribution of CI is symmetric about 1 was performed. Statistically significant differences are indicated by symbols when present: *: p<0.05; **: p<0.01. The data are pooled from two or three independent experiments.