Table 1.
Parameters of fast and slow T-currents in NTCN neurons.
| Control | C, pF | T-current parameters at −45 mV | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
Peak current density, pA/pF |
Time constant of activation, ms |
Time constant of inactivation, ms |
|||||||
| Fast | Slow | Fast | Slow | Fast | Slow | Fast | Slow | ||
| 18.8 ± 1.0 | 12.8 ± 1.5 | 2.8 ± 0.3 | 5.2 ± 0.5 | 6.6 ± 0.6 | 7.2 ± 0.8 | 26 ± 2 | 76 ± 5 | ||
| Diabetes | Hyperalgesia | 15.5 ± 1.4 | 4.4 ± 0.4 | 5.0 ± 0.9 | 27 ± 4 | ||||
| Hypoalgesia | 17.9 ± 1.0 | 17.7 ± 1.0 | 2.6 ± 0.4 | 2.0 ± 0.6 | 7.7 ± 1.6 | 6 ± 1 | 27 ± 3 | 66 ± 4 | |
| Normalgesia | 2.6 ± 2.2 | 13.3 ± 1.0 | 2.5 ± 0.5 | 1.9 ± 0.5 | 6.1 ± 0.7 | 3.2 ± 0.3 | 23 ± 2 | 66 ± 8 | |