Table 2.
Parameters of T-current activation and steady-state inactivation.
Control | Steady-state inactivation | Activation | |||||||
---|---|---|---|---|---|---|---|---|---|
V 1/2, mV | k, mV | V 1/2, mV | k, mV | ||||||
Fast | Slow | Fast | Slow | Fast | Slow | Fast | Slow | ||
−90 ± 2 | −88 ± 4 | 5.9 ± 0.6 | 5.7 ± 0.7 | −49.3 ± 1.3 | −46 ± 2 | 5.1 ± 0.7 | 5.7 ± 1.2 | ||
Diabetes | Hyperalgesia | −81.3 ± 1.7 | 6.0 ± 0.2 | −48.9 ± 1.6 | 5.2 ± 0.3 | ||||
Hypoalgesia | −96 ± 4 | −82 ± 2 | 4.3 ± 1.6 | 5.3 ± 0.5 | −50 ± 4 | −49.9 ± 1.7 | 7 ± 3 | 4.1 ± 0.8 | |
Normalgesia | −85 ± 2 | −80.1 ± 1.0 | 5.6 ± 0.4 | 6.4 ± 0.2 | −51.7 ± 1.4 | −49 ± 2 | 6.3 ± 0.9 | 5.9 ± 0.8 |