Figure 2.

Continuous chelerythrine reduces locomotor sensitization. (A) Mice were implanted with osmotic pumps containing chelerythrine or vehicle. Chelerythrine (n = 9 Chel, n = 8 Veh) was delivered continuously, ICV (10 nmol/μL, 0.25 μL/h), across six sessions of cocaine administration (15 mg/kg, i.p.). Average distance traveled (±s.e.m.) during each session is depicted. Chelerythrine did not alter the acute response to cocaine [ANOVA, F_{(1, 15)} = 0.097, p = 0.76] but did reduce the development of sensitization across the six sessions. (B) Sensitization, measured as the difference in distance traveled between the acute (session 1) and sensitized (session 6) response was significantly impaired in mice receiving chelerythrine across 15 min [MANOVA, F_{(1, 15)} = 11.1, p < 0.01]. The difference in distance traveled (± s.e.m.) is shown for each minute. (C) Average sensitization (±s.e.m.) measured as the difference in distance traveled is shown for each group.