Skip to main content
. 2014 Mar 7;8:70. doi: 10.3389/fnbeh.2014.00070

Figure 3.

Figure 3

Single pre- but not post-induction application of ZIP reduces locomotor sensitization. (A) Mice received a single pre-induction infusion of ZIP (10 nmol/μL, 1 μL). Sensitization was induced during two sessions of cocaine administration (15 mg/kg, i.p.). ZIP was administered 2 h prior to the first cocaine administration session (n = 13 ZIP, n = 13 aCSF), indicated by the arrow. The average distance traveled (±s.e.m.) for each session is shown. While on-ZIP, the acute response to cocaine was not altered [ANOVA, F(1, 24) = 0.215, p = 0.65]. Cocaine was given for a second time, 48 h later, during session 2. When measured off-ZIP, distance traveled was significantly reduced in animals that had previously received ZIP [ANOVA, F(1, 24) = 5.8, p < 0.05]. (B) Sensitization was significantly reduced in animals given ZIP prior to cocaine administration [ANOVA, F(1, 24) = 5.7, p < 0.05]. Sensitization is represented as the average difference in distance traveled (±s.e.m.) between the two sessions. (C) Mice received a single post-induction infusion of ZIP (10 nmol/μL, 1 μL). Sensitization was induced across 4 sessions of cocaine administration (15 mg/kg, i.p.), after which mice were given a single infusion of ZIP, represented by the arrow. Post-induction ZIP did not produce impairment when sensitization was assessed 72 h later off-ZIP (ZIP n = 9, Veh n = 8). (D) A single infusion of ZIP reduces AMPAR density following sensitization. H3 counts (±s.e.m.) for each group are depicted.