Table 3.
Evaluation of IC50 values for quercetin Q and its derivatives 1-15 determined by MTT assay on human cervical cancer cells HeLa and non-cancer murine fibroblast cells NIH-3T3 (time of drug exposure 72 h).
| No. | Compound | IC50 ± SD | |
|---|---|---|---|
| HeLa cells | NIH-3T3 cells | ||
| 1 | diquercetin | 64.0±7.5 | 32.9±1.1 |
| 2 | monochloropivaloyl quercetin | 43.4±2.8 | 26.8±0.5 |
| 3 | tri(monochloropivalyol) quercetin | 65.0±4.5 | 20.3±1.9 |
| 4 | 5-morfolinohydroxypropoxy quercetin | >100 | >100 |
| 5 | chloronaphtoquinone quercetin | 13.2±1.6 | 16.5±0.1 |
| 6 | pentaacetyl quercetin | 29.6±1.9 | 15.5±0.7 |
| 7 | tri(diprenylcaffeoyl) quercetin | >50 | >50 |
| 8 | di(diprenylcaffeoyl) quercetin | >50 | >50 |
| 9 | di(tetraacetylquinoyl) quercetin | 19.5±0.8 | 16.1±0.4 |
| 10 | tri(trimethylgalloyl) quercetin | >50 | >50 |
| 11 | tri(diacetylcaffeoyl) quercetin | 16.5±1.5 | 10.6±0.1 |
| 12 | tetra(acetylsalicyloyl) quercetin | >50 | >50 |
| 13 | tri(acetylferuloyl) quercetin | >50 | >50 |
| 14 | di(prenylferuloyl) quercetin | >50 | >50 |
| 15 | monoacetylferuloyl quercetin | >50 | >50 |
| Q | quercetin | 35.5±1.1 | 20.9±0.9 |
| T | trolox | 34.7±1.0 | 39.5±2.1 |
Values are in µM, mean of five experimental samples ± standard deviation.