Vault structure and adsorption geometry. (A) Side view of a vault from x-ray data (3). The MVP is enlarged in the structure (green line). The MVP is composed of 12 domains, nine structural repeat domains at the N-terminus, an α/β shoulder domain, a cap-helix domain, and a cap-ring domain at the C-terminus. (B) General topography image of vaults in buffer conditions showing upright (yellow arrow) reclining (white arrow) and half-vault orientations (green arrow). Scale bar, 75 nm. To see this figure in color, go online.