Table 2. Tabel 2. Summary ORs and 95% CIs of the association between VDR gene polymorphism and type 1 diabetes mellitus risk.
SNPs | Regional geograph | A vs a | AA vs Aa+aa | aa vs AA+Aa | AA vs Aa | AA vs aa | |||||
OR(95%CI) | P | OR(95%CI) | P | OR(95%CI) | P | OR(95%CI) | P | OR(95%CI) | P | ||
BsmI | overall | 1.47(1.13,1.91) | 0.004 | 1.72(1.16,2.57) | 0.004 | 0.44(0.29,0.65) | <0.001 | 1.45(1.09,1.91) | 0.01 | 2.23(1.62,3.07) | <0.001 |
East Asian | 1.97(1.38,2.83) | <0.001 | 3.20(1.39,7.33) | <0.001 | 0.36(0.20,0.63) | <0.001 | 1.72(0.91,3.26) | 0.022 | 4.71(2.44,9.08) | 0.038 | |
West Asian | 0.90(0.52,1.56) | 0.704 | 1.32(0.83,2.10) | 0.704 | 0.52(0.20,1.36) | 0.185 | 1.75(1.09,2.82) | 0.097 | 1.75(1.07,2.85) | 0.027 | |
FokI | overall | 1.14(0.92,1.41) | 0.234 | 1.16(0.90,1.51) | 0.26 | 0.77(0.49,1.22) | 0.271 | 1.16(0.91,1.48) | 0.226 | 1.11(0.91,1.36) | 0.789 |
East Asian | 1.00(0.74,1.35) | 0.995 | 0.99(0.65,1.51) | 0.961 | 0.99(0.65,1.50) | 0.947 | 0.90(0.69,1.43) | 0.967 | 0.96(0.73,1.26) | 0.657 | |
West Asian | 1.45(1.12,1.88) | 0.004 | 1.46(1.11,1.92) | 0.006 | 0.24(0.06,1.02) | 0.052 | 1.44(1.06,1.96) | 0.019 | 1.45(1.12,1.88) | 0.004 |
SNPs: single nucleotide polymorphisms.
A represent B allele and a represent b allele for BsmI, A present F allele and a represent f allele for FokI, respectively.