Table 2.

Changes from M0 to M24 in plasma markers of inflammation and immune activation (log _e -transformed values)

		Total n = 78	TDF/ FTC n = 61	ABC/ 3TC n = 17	EFV n = 36	ATV/r n = 27	LPV/r n = 15
IL-6	Baseline (pg/ml)	1.6 (1.1-2.5)	1.6 (1.1-2.6)	1.2 (0.99-1.7)	1.6 (1.1-2.5)	1.2 (0.88-2.4)	2.17 (1.1-7.4)
	Mean fold change (95% CI)	0.60 (0.49, 0.74)	0.60 (0.48, 0.77)	0.60 (0.36, 0.99)	0.59 (0.42, 0.83)	0.82 (0.64, 1.05)	0.36 (0.20, 0.67)
	P value*	<0.001
hs-CRP	Baseline (mg/L)	4 (2.2-15)	4.2 (2.3-15)	2.7 (1.8-9.4)	3.9 (2.2-17.8)	3 (2-5.9)	7.5 (2.9-20)
	Mean fold change (95% CI)	0.77 (0.57, 1.1)	0.81 (0.56, 1.20)	0.66 (0.33, 1.30)	0.76 (0.46, 1.26)	0.88 (0.54, 1.44)	0.63 (0.27, 1.47)
	P value	0.11
sCD14	Baseline (106 pg/ml)	2.6 (2.1-3.1)	2.6 (2.2-3.1)	2.5 (2-3.1)	2.5 (2.2-3)	2.6 (1.7-3.1)	3.1 (2-3.4)
	Mean fold change (95% CI)	1.00 (0.93, 1.1)	1.00 (0.93, 1.10)	0.96 (0.79, 1.15)	0.95 (0.85, 1.06)	1.10 (0.93, 1.26)	1.00 (0.85, 1.20)
	P value	0.82
IP-10	Baseline (pg/ml)	664 (431-960)	630 (435-974)	721 (431-895)	692 (447-996)	549 (389-781)	798 (470-1326)
	Mean fold change (95% CI)	0.41 (0.35, 0.49)	0.44 (0.36, 0.52)	0.37 (0.27, 0.49)	0.34 (0.28, 0.42)	0.53 (0.40, 0.71)	0.43 (0.27, 0.67)
	P value	<0.001
MIG	Baseline (pg/ml)	1532 (980-2804)	1534 (1004-2804)	1431 (938-2562)	1908 (1093-3799)	1182 (920-2201)	1611 (887-2444)
	Mean fold change (95% CI)	0.26 (0.19, 0.33)	0.25 (0.18, 0.35)	0.27 (0.17, 0.42)	0.16 (0.10, 0.24)	0.39 (0.30, 0.51)	0.39 (0.22, 0.70)
	P value	<0.001

TDF, Tenofovir; FTC, Emtricitabine; ABC, Abacavir; 3TC, Lamivudine; EFV, Efavirenz; ATV/r, Atazanavir/ritonavir; LPV/r, Lopinavir/ritonavir; IL-6, Interleukin-6; hs-CRP, Highly sensitive C-reactive protein; sCD14, soluble CD14; 1P10, Interferon-γ-Inducible Protein 10; MIG, Monokine induced by interferon-γ; CI, Confidence Interval.

*One-sample Student’s t test of the change of each marker in the overall study sample.