Table 3. Basic information of Alleles and allele association results Between DR and DWR groups.
| Gene | locus | SNP | position |
Minor |
MAF |
HWpval |
OR (CI) |
P |
|
|---|---|---|---|---|---|---|---|---|---|
| Allele | DR DWR | value | |||||||
|
PPARγ |
3 |
rs1805192 |
12,396,238 |
G |
0 |
||||
|
KDR |
4 |
rs2071559 |
55,687,123 |
C |
0.34 |
0.39 |
0.022 |
1.41(1.07,1.86) |
0.011 |
| rs13109660 |
55,665,437 |
A |
0.31 |
0.63 |
0.49 |
1.06(0.8,1.41) |
0.66 |
||
| rs1870378 |
55,661,210 |
A |
0.48 |
0.67 |
0.33 |
0.92(0.71,1.21) |
0.55 |
||
| rs1870377 |
55,667,731 |
A |
0.48 |
0.4 |
0.73 |
0.95(0.73,1.23) |
0.67 |
||
|
VEGF |
6 |
rs699947 |
43,844,367 |
A |
0.28 |
0.009 |
0.51 |
1.63(1.22,2.18) |
0.001 |
| rs833061 |
43,845,464 |
C |
0.28 |
0.021 |
0.33 |
1.53(1.14,2.04) |
0.003 |
||
| rs13207351 |
43,845,772 |
A |
0.28 |
0.01 |
0.41 |
1.58(1.18,2.12) |
0.001 |
||
| rs2010963 |
43,846,328 |
C |
0.44 |
0.41 |
0.9 |
0.87(0.67,1.13) |
0.29 |
||
| rs833069 |
43,850,557 |
G |
0.44 |
1 |
0.9 |
0.92(0.71,1.2) |
0.53 |
||
| rs2146323 |
43,853,073 |
A |
0.26 |
0.003 |
0.49 |
1.52(1.13,2.05) |
0.004 |
||
| rs3025021 |
43,857,141 |
T |
0.16 |
0.58 |
1 |
1.36(0.95,1.97) |
0.083 |
||
| rs3025039 |
43,860,514 |
T |
0.09 |
1 |
0.38 |
1.34(0.96,1.88) |
0.077 |
||
|
EPO |
7 |
rs507392 |
100,157,872 |
C |
0.2 |
0.4 |
0.03 |
0.93(0.67,1.28) |
0.64 |
| rs551238 |
100,159,464 |
C |
0.2 |
0.39 |
0.045 |
1.04(0.75,1.45) |
0.8 |
||
| rs1617640 |
100,155,234 |
G |
0.19 |
0.1 |
0.14 |
1.18(0.85,1.66) |
0.31 |
||
|
AKR1B1 |
7 |
rs759853 |
133,794,498 |
A |
0.07 |
0.79 |
0.34 |
1.31(0.92,1.87) |
0.11 |
|
PKC-β |
16 |
rs3900007 |
23,754,453 |
G |
0.42 |
0.49 |
0.22 |
1.01(0.78,1.31) |
0.95 |
| rs3900008 |
23,754,514 |
C |
0.3 |
<0.001 |
<0.001 |
1.05(0.78,1.41) |
0.75 |
||
| rs11645239 |
23,754,563 |
G |
0.36 |
||||||
| rs2575390 |
23,754,255 |
G |
0.06 |
1 |
1 |
0.95(0.53,1.69) |
0.85 |
||
| rs3760106 |
23,753,297 |
A |
0.06 |
1 |
1 |
1.02(0.57,1.84) |
0.95 |
||
|
ACE |
17 |
rs1800764 |
58,904,261 |
C |
0.39 |
1 |
1 |
1.23(0.94,1.6) |
0.12 |
| rs9896208 |
58,929,841 |
T |
0.42 |
0.26 |
0.021 |
0.95(0.73,1,24) |
0.71 |
||
| ICAM-1 | 19 | rs5498 |
10,256,683 |
G |
0.31 |
0.64 |
0.1 |
1.32(1,1.75) |
0.044 |
| rs1799969 | 10,255,792 | A | 0.003 | ||||||
MAF: minor allele frequency; HWpval: p value for Hardy–Weinberg (H-W) equilibrium; OR: odds ratio; CI:95% confidence interval; Genotype distributions for SNPs were in Hardy–Weinberg (H-W) equilibrium, except rs3900008 in both groups.