Table 5. Association analysis of polymorphisms in multivariate models.
| Gene | SNP | genotype | Ajusted OR (CI) | P value |
|---|---|---|---|---|
| KDR |
rs2071559 |
TT |
0.05 |
|
| CT |
1.57 (1.01,2.44) |
|||
| CC |
1.87 (1.01,3.48) |
|||
| rs1870377 |
TT |
0.64 |
||
| TA |
1.13 (0.69,1.85) |
|||
| AA |
0.88 (0.48,1.6) |
|||
| rs1870378 |
GG |
0.79 |
||
| GA |
1.1 (0.66,1.81) |
|||
| AA |
0.91 (0.5,1.66) |
|||
| rs13109660 |
GG |
0.93 |
||
| GA |
1.01 (0.48,2.13) |
|||
| AA |
1.09 (0.7,1.68) |
|||
| VEGF |
rs699947 |
CC |
0.002 |
|
| CA |
1.26 (0.82,1.95) |
|||
| AA |
3.74 (1.75,8.00) |
|||
| rs833061 |
TT |
0.004 |
||
| CT |
1.19 (0.77,1.85) |
|||
| CC |
3.50 (1.62,7.54) |
|||
| rs13207351 |
GG |
0.002 |
||
| GA |
1.22 (0.79,1.89) |
|||
| AA |
3.64 (1.71,7.77) |
|||
| rs2146323 |
CC |
0.014 |
||
| CA |
1.14 (0.73,1.77) |
|||
| AA |
2.88 (1.4,5.93) |
|||
| rs3025021 |
TT |
|||
| CT |
0.75 (0.2,2.78) |
0.22 |
||
| CC |
1.14 (0.32,4.06 |
|||
| rs833069 |
GG |
|||
| GA |
1.09 (0.63,1.89) |
0.63 |
||
| AA |
1.3 (0.73,2.34) |
|||
| rs2010963 |
GG |
|||
| GC |
0.89 (0.56,1.41) |
0.51 |
||
| CC |
0.7 (0.38,1.28) |
|||
| rs3025039 |
CC |
0.23 |
||
| CT |
1.23 (0.79,1.92) |
|||
| TT |
2.8 (0.76,10.27) |
|||
| ICAM-1 |
rs5498 |
AA |
0.091 |
|
| GA |
1.44 (0.94,2.22) |
|||
| GG |
2.04 (0.94,4.44) |
|||
| EPO |
rs507392 |
TT |
0.88 |
|
| CT |
1.02 (0.65,1.61) |
|||
| CC |
0.8 (0.32,2.02) |
|||
| rs551238 |
AA |
0.94 |
||
| CA |
1.07 (0.67,1.68) |
|||
| CC |
0.92 (0.36,2.36) |
|||
| rs1617640 |
TT |
|||
| GT |
0.85 (0.53,1.36) |
0.79 |
||
| GG |
0.94 (0.36,2.41) |
|||
| AKR1B1 |
759853 |
GG |
0.11 |
|
| GA |
0.62 (0.39,0.99) |
|||
| AA |
0.59 (0.17,2.05) |
|||
| ACE |
1800764 |
TT |
0.33 |
|
| CT |
0.87 (0.56,1.37) |
|||
| CC |
0.62 (0.33,1.16) |
|||
| rs9896208 |
CC |
|||
| TC |
0.62 (0.39,0.97) |
0.097 |
||
| TT |
0.88 (0.47,1.63) |
|||
| PRK-β | 3900007 |
AA |
0.82 |
|
| GA |
1.14 (0.72,1.8) |
|||
| GG |
1.17 (0.64,2.14) |
|||
| 2575390 |
CC |
0.78 |
||
| CG |
0.89 (0.46,1.71) |
|||
| GG |
2.73 (0.1,73.85) |
|||
| 3760106 |
GG |
0.81 |
||
| GA |
2.67 (0.1,71.35) |
|||
| AA | 0.92 (0.48,1.77) |
Multiple logistic regression analysis was used to calculate odds ratio (OR) and 95% confidence interval (CI) by comparing diabetic retinopathy (DR) group with diabetic without retinopathy (DWR) group, which include the most significant SNP at kinase insert domain receptor gene (KDR) gene (rs2071559), vascular endothelial growth factor (VEGF) gene (rs833061, rs13207351, rs699947, rs2146323). Adjusted OR represents data after adjustment for covariates including age of diabetic onset, duration, high albuminuria, insulin use, glycosylated hemoglobin A1c (HbA1c), fasting plasma glucose and creatinine levels.