Table 6. Haplotype association analysis between polymorphisms and risk of diabetic retinopathy in patients with type 2 diabetes mellitus.
| Haplotype blocks | DR group (%) | DWR group (%) | OR (95%CI) | Chi Square | p value |
|---|---|---|---|---|---|
| Block 1 |
|||||
| AAG |
48.7 |
47.2 |
1.07 (0.82, 1.39) |
0.26 |
61 |
| TGA |
29.5 |
31.2 |
0.93 (0.69, 1.23) |
0.28 |
0.59 |
| TGG |
20.7 |
20.8 |
0.99(0.72–1.37) |
0.001 |
0.98 |
| Block 2 |
|||||
| ACGA |
32.4 |
23.2 |
1.58 (1.19, 2.10) |
9.87 |
0.002 |
| CTCG |
42.1 |
44.6 |
0.90 (0.69, 1.16) |
0.68 |
0.41 |
| CTGG |
25.2 |
31.6 |
0.73(0.55, 0.97) |
4.8 |
0.03 |
| Block 3 |
|||||
| AA |
30.7 |
22.5 |
1.53 (1.15, 2.04) |
8.39 |
0.04 |
| AC |
25.8 |
32.4 |
0.72 (0.55, 0.96) |
5.16 |
0.02 |
| GC |
43.4 |
44.8 |
0.94 (0.73, 1.21) |
0.23 |
0.63 |
| Block 4 |
|||||
| CGA |
57.3 |
57.9 |
0.97(0.75, 1.26) |
0.044 |
0.83 |
| CGG |
37.1 |
36.3 |
1.04(0.80, 1.35) |
0.068 |
0.79 |
| GAG |
5.6 |
5.8 |
0.97(0.57, 1.68) |
0.009 |
0.92 |
| Block 5 |
|||||
| CCG |
17.5 |
20 |
0.86(0.62, 1.20) |
0.79 |
0.37 |
| TAT | 80.6 | 79.4 | 1.16(0.84, 1.61) | 0.79 | 0.37 |
Data were given as frequency of each haplotype within diabetic retinopathy (DR) group or diabetic without retinopathy (DWR) group. Block 1 included rs1870378, rs13109660, and rs1870377 in kinase insert domain receptor gene. block 2 included promoter SNPs rs699947, rs833061, rs13207351 and rs2010963 at 5′ UTR, and Block3 included SNPs two intronic SNPs of rs833069 rs2146323 in vascular endothelial growth factor gene, Block4 included SNPs rs3760106 rs2575390 rs3900007 in protein kinase C-β gene, block 5, rs1617640 rs507392 rs551238 in erythropoietin gene. Only haplotypes with frequency over 3% were included in this table. OR indicates odds ratio and CI refers to confidence interval.