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. 2014 Feb 28;15:10. doi: 10.1186/2050-6511-15-10

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Copyright © 2014 Gurtskaia et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Post treatment with naloxone after microinjections of NSAIDs into the DH results in a significant decrease in TF latency for the first day for clodifen (A), ketorolac (B), and xefocam (C), respectively (P < 0.001). On the second and third days, there are generally trend effects for all three non-opioid analgesics. The same decreases of latencies are observed in HP test for clodifen (D) (P < 0.01), ketorolac (E) (P < 0.001), and xefocam (F) (P < 0.001), respectively. Number of rats N = 5/groups. *- P < 0.05, **- P < 0.01, ***- P < 0.001.