Table 4.
Anti-malarial activity in vitro in 15 different human P . vivax isolates for chloroquine (CQ), artesunate (ART) and mefloquine MQ)
|
P
.
vivax
isolates |
% of trophozoites |
Drugs/IC
50
Nm |
||
|---|---|---|---|---|
| CQ | ART | MQ | ||
| P006 |
22 |
29 |
15 |
11 |
| P010 |
20 |
61** |
11 |
45 |
| P015 |
9 |
13.5 |
11 |
6 |
| P022 |
15 |
8 |
11 |
60 |
| P024 |
32* |
69** |
34 |
113 |
| P025 |
93* |
3.0 |
28 |
11 |
| P026 |
29 |
51** |
137 |
42 |
| P028 |
11 |
6.6 |
2.8 |
11 |
| P029 |
16 |
34 |
2.5 |
5.5 |
| P031 |
10 |
15 |
8.0 |
8.2 |
| P033 |
8 |
23 |
23 |
24 |
| P034 |
17 |
29 |
9.6 |
47 |
| P038 |
42* |
8.5 |
1.3 |
2 |
| P037 |
32* |
6.5 |
9.4 |
39 |
| P039 |
88* |
6.8 |
5.2 |
26 |
| P042 |
80* |
62** |
23 |
15 |
| Mean (±SD) | - | 23 + 9 | 32 + 37 | 32 + 28 |
*Isolates that presented more than 30% trophozoites. **Isolates that were considered less sensitive to CQ.