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. 2014 Jan 7;19(1):122–134. doi: 10.1016/j.cmet.2013.11.015

Figure 7.

Figure 7

Administration of the Ketogenic Diet during Insulin Resistance Rescues miR-184 Expression

(A) Quantitative real-time PCR analysis of miR-184 and miR-375 in islets of 10-week-old C57BL/6 mice on chow (Chow) or ketogenic diet (Keto) for 24 days (n = 4).

(B) Blood glucose levels during an ITT on 10-week-old Chow and Keto mice for 24 days (n = 4–5).

(C and D) Plasma insulin and blood glucose levels after glucose challenge on 10-week-old Chow and Keto mice for 24 days (n = 4–5).

(E) Quantitative real-time PCR analysis of miR-184 and miR-375 in islets of 16-week-old ob/ob mice on chow or ketogenic diet and WT littermates (n = 4).

(F and G) Blood glucose and random plasma insulin levels in 16-week-old ob/ob mice on chow (Chow/ob) or ketogenic diet (Keto/ob) for 15 days (n = 4).

(H) Blood glucose levels during an ITT on 16-week-old ob/ob mice on chow or ketogenic diet for 15 days (n = 4–5).

(I and J) Plasma insulin and blood glucose levels after glucose challenge on 16-week-old ob/ob mice on chow or ketogenic diet for 15 days (n = 4-5).

(K and L) Quantification of β cell mass after immunostaining pancreatic sections for insulin (green) of 16-week-old ob/ob mice on chow or ketogenic diet for 45 days (n = 3). Scale bars = 200 μm.

(M) Quantitative real-time PCR analysis of Ago2 and Slc25a22 in islets of 16-week-old ob/ob mice on chow or ketogenic diet (n = 4–5). Results presented as mean ± SEM. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.

See also Figure S7.