Table 3.

Cox regression analyses. Variables that remained in the final model with P < 0.05 were identified as predictors of survival

	HR	95% CI for HR	P-valuea
Actual survival
Age ≥62 years	1.54	0.95–2.48	0.075
High CRS (≥3)	1.78	1.10–2.89	0.018
ED present	1.15	0.55–2.43	0.699
RM of ≤ 1 mm	1.31	0.79–2.17	0.285
Grade of metastases II or III	1.73	0.98–3.03	0.055
p53+	1.35	0.81–2.22	0.239
Ki-67 +	0.82	0.68–0.98	0.038
TS+	1.07	0.63–1.80	0.789
Disease-free survival
Age ≥62 years	1.11	0.70–1.76	0.650
High CRS (≥3)	1.81	1.15–2.86	0.010
ED present	2.11	1.09–4.07	0.025
RM of ≤ 1 mm	1.26	0.76–2.09	0.371
Grade of metastases II or III	1.54	0.92–2.56	0.096
p53+	1.18	0.74–1.88	0.492
Ki-67 +	0.88	0.73–1.05	0.161
TS+	0.97	0.59–1.60	0.927

^aValues in bold are significant at P < 0.05.

HR, hazard ratio; 95% CI, 95% confidence interval; CRS, clinical risk score; ED, extrahepatic disease; RM, resection margin; TS, thymidiylate synthase.