Figure 1. Progressive degeneration of pericytes in APP^sw/0Pdgfrβ^+/− mice.

(a) Confocal microscopy analysis of CD13-positive pericytes and lectin-positive capillary endothelium in the cortex of 9-month-old Pdgfrβ^+/+, Pdgfrβ^+/−, APP^sw/0; Pdgfrβ^+/+ and APP^sw/0; Pdgfrβ^+/− mice. Scale bar, 100 μm. (b) Quantification of CD13-positive pericytes in the cortex and hippocampus of 1-, 3-, 6- and 9-month-old Pdgfrβ^+/+, Pdgfrβ^+/−, APP^sw/0; Pdgfrβ^+/+ and APP^sw/0; Pdgfrβ^+/− age-matched littermates. Mean±s.e.m., n=6 mice per group. Data from the cortex and hippocampus were pooled because there were no significant differences between these two regions. *P<0.05, all other groups compared with Pdgfrβ^+/+; ^#P<0.05, APP^sw/0; Pdgfrβ^+/− compared with APP^sw/0; Pdgfrβ^+/+; ^§P<0.05, APP^sw/0; Pdgfrβ^+/− compared with Pdgfrβ^+/−. All comparisons are by analysis of variance (ANOVA) followed by Tukey’s post-hoc tests.