Table III. Proteins included in the optimized OPLS-DA model.
| Gene name | UniProt entry | Protein name | FC | q-value |
|---|---|---|---|---|
| SOD2 | P04179 | Superoxide dismutase [Mn], mitochondrial | 4.1 | 0.0 |
| AFF3 | P51826 | AF4/FMR2 family, member 3 | 2.8 | 20.2 |
| THBS1 | P07996 | Thrombospondin-1 | 2.4 | 0.0 |
| ATP5A1 | P25705 | ATP synthase subunit α | 2.3 | 34.6 |
| COL6A1 | P12109 | Collagen, type VI, α 1 | 2.1 | 20.2 |
| RPL21 | P46778 | 60S ribosomal protein L21 | 1.8 | 40.4 |
| RAB1B | E9PLD0 | Ras-related protein Rab-1B | 1.7 | 45.8 |
| SEPT10 | Q9P0V9 | Septin 10 | −1.1 | 76.4 |
| C8B | P07358 | Complement component C8 β chain | −1.1 | 76.5 |
| DSG2 | Q14126 | Desmoglein-2 | −1.2 | 67.6 |
| KNTC1 | P50748 | Kinetochore-associated protein 1 | −1.3 | 66.4 |
| TUBA1B | P68363 | Tubulin α-1B chain | −1.3 | 68.9 |
| HGFAC | Q04756 | Hepatocyte growth factor activator | −1.4 | 66.4 |
| ICAM1 | P05362 | Intercellular adhesion molecule 1 | −1.5 | 65.1 |
| CP | P00450 | Ceruloplasmin | −1.5 | 65.1 |
| KRT71 | Q3SY84 | Keratin, type II cytoskeletal 71 | −1.5 | 65.1 |
| ZNF704 | Q6ZNC4 | Zinc finger protein 704 | −1.5 | 65.1 |
| C8G | P07360 | Complement component C8 γ chain | −1.5 | 64.1 |
| ZNF670 | Q9BS34 | Zinc finger protein 670 | −1.5 | 67.6 |
| C9 | P02748 | Complement component C9 | −1.6 | 64.1 |
| C1S | P09871 | Complement component 1, s subcomponent | −1.6 | 64.1 |
| COL3A1 | P02461 | Collagen α-1(III) chain | −1.6 | 65.1 |
| GOLM1 | Q8NBJ4 | Golgi membrane protein 1 | −1.7 | 64.1 |
| C16orf71 | Q8IYS4 | Uncharacterized protein C16orf71 | −1.7 | 65.1 |
| SDC1 | P18827 | Syndecan-1 | −1.8 | 64.1 |
| NRP1 | O14786 | Neuropilin 1 | −1.8 | 64.1 |
| HRG | P04196 | Histidine-rich glycoprotein | −1.8 | 64.1 |
| F12 | P00748 | Coagulation factor XII | −1.9 | 64.1 |
| LRRC28 | Q86X40 | Leucine-rich repeat-containing protein 28 | −2.0 | 64.1 |
| SERPINA4 | P29622 | Kallistatin (KAL) | −2.0 | 64.1 |
| LRG1 | P02750 | Leucine-rich α-2-glycoprotein | −2.1 | 64.1 |
| MMRN2 | Q9H8L6 | Multimerin 2 | −2.3 | 64.1 |
| POU4F3 | Q15319 | POU domain, class 4, transcription factor 3 | −2.3 | 64.1 |
| LAMA4 | Q16363 | Laminin, α 4 | −2.5 | 64.1 |
| FBF1 | Q8TES7 | Fas binding factor 1 | −2.5 | 64.1 |
| FXYD3 | Q14802 | FXYD domain-containing ion transport regulator 3 | −2.6 | 64.1 |
| C4BPA | P04003 | C4b-binding protein α chain | −3.0 | 64.1 |
Fold-change (FC) and q-values (false discovery rate in percentages) were calculated with significant analysis of microarray based on the same patients included in the model. Positive FC = up-regulated and negative FC = down-regulated in effusions from mesothelioma patients relative to those from lung adenocarcinoma patients.