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. 2014 Jan 20;13(3):887–896. doi: 10.1074/mcp.M113.031294

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 2. — Assembly construction based on PRISM binary predictions. First PRISM predicts binary interactions among target proteins. Then, assembly is constructed in an iterative process. N − 2 iterations are needed to construct an N-component assembly. Proteins are added one by one at each iteration based on PRISM binary predictions. There the protein to be added is transformed according to the PRISM prediction and the flexible refinement step of PRISM is run for the addition. The protein is added if the energy calculated is favorable.