Table 1.

Univariate hazard ratios for metastasis, cancer-specific mortality, and all-cause mortality among 28 tested very-high-risk definitions

		Metastasis			Cancer-specific mortality			All-cause mortality
	Tested very-high-risk definitions	H.R.	p	95% C.I.	H.R.	p	95% C.I.	H.R.	p	95% C.I.	JHU very high risk sample size
1	Any pattern 5 or pattern 4 + PSA >20 or pattern 4 + ≥cT3a	2.26	<0.001	1.53, 3.32	2.54	<0.001	1.52, 4.26	1.80	0.002	1.24, 2.61	328 (43.6%)
2	Any pattern 5 or Gleason 8 + PSA >20 or Gleason 8 + ≥cT3a	2.38	<0.001	1.60, 3.55	3.78	<0.001	2.31, 6.18	2.55	<0.001	1.74, 3.74	190 (25.2%)
3	Multiple high-risk features	2.53	<0.001	1.44, 4.43	2.91	<0.001	1.55, 5.45	2.12	0.005	1.25, 3.59	45 (6.0%)
4	Any pattern 5	2.16	<0.001	1.42, 3.27	3.44	<0.001	2.08, 5.69	2.47	<0.001	1.66, 3.68	171 (22.7%)
5	Primary pattern 5	3.98	<0.001	2.28, 6.96	4.82	<0.001	2.43, 9.58	3.20	<0.001	1.78, 5.76	52 (6.9%)
6	Any pattern 5 or multiple high-risk features	2.40	<0.001	1.62, 3.55	3.90	<0.001	2.39, 6.36	2.57	<0.001	1.76, 3.75	197 (26.2%)
7	Any pattern 5 or ≥4 cores with pattern 4	2.31	<0.001	1.57, 3.39	2.97	<0.001	1.81, 4.89	2.05	<0.001	1.39, 3.01	286 (38.0%)
8	Any pattern 5 or ≥4 cores with pattern 4 or multiple high-risk feat	2.54	<0.001	1.73, 3.73	3.28	<0.001	2.00, 5.39	2.06	<0.001	1.42, 3.00	304 (40.4%)
9	Primary pattern 5 or multiple high-risk features	3.15	<0.001	2.02, 4.91	3.73	<0.001	2.20, 6.33	2.57	<0.001	1.67, 3.97	90 (12.0%)
10	Primary pattern 5 or ≥4 cores with pattern 4	2.55	<0.001	1.70, 3.83	2.52	<0.001	1.44, 4.43	1.62	0.038	1.03, 2.66	201 (26.7%)
11	Primary pattern 5 or ≥4 cores with pattern 4 or multiple high-risk feat	2.78	<0.001	1.89, 4.10	2.76	<0.001	1.66, 4.57	1.76	0.007	1.17, 2.66	227 (30.1%)
12	Any pattern 5 or max pattern 4 or 5 per core >50%	2.31	<0.001	1.56, 3.41	2.32	<0.001	1.41, 3.81	1.82	0.002	0.25, 2.65	368 (48.9%)
13	Any pattern 5 or max pattern 4 or 5 per core >50% or mult hi risk feat	2.63	<0.001	1.76, 3.92	2.74	<0.001	1.65, 4.55	1.92	0.002	1.32, 2.80	384 (51.0%)
14	Primary pattern 5 or ≥4 cores with pattern 4/5	2.51	<0.001	1.67, 3.77	2.50	<0.001	1.42, 4.40	1.63	0.042	1.02, 2.63	204 (27.1%)
15	Primary pattern 5 or ≥4 cores with pattern 4/5 or mult high-risk feat	2.74	<0.001	1.86, 4.05	2.74	<0.001	1.65, 4.54	1.75	0.007	1.16, 2.64	230 (30.5%)
16	Primary pattern 5 or ≥4 cores with pattern 4/5 or PNI	2.12	<0.001	1.45, 3.10	1.86	<0.001	1.14, 3.05	1.32	0.150	0.90, 1.94	308 (40.9%)
17	Primary pattern 5 or PNI	2.21	<0.001	1.51, 3.23	1.95	<0.001	1.18, 3.20	1.42	0.076	0.96, 2.10	234 (31.1%)
18	Primary pattern 5 or ≥1 core with sum 8–10 or multiple high-risk features	1.82	<0.001	1.22, 2.70	2.93	<0.001	1.71, 5.05	1.84	0.002	1.25, 2.69	455 (60.4%)
19	Primary pattern 5 or ≥2 cores with sum 8–10 or multiple high-risk features	2.25	<0.001	1.54, 3.30	2.79	<0.001	1.71, 4.56	1.75	0.004	1.19, 2.56	267 (35.5%)
20	Primary pattern 5 or ≥3 cores with sum 8–10 or multiple high-risk features	2.72	<0.001	1.83, 4.04	3.17	<0.001	1.92, 5.23	2.04	0.001	1.36, 3.07	176 (23.4%)
21	Primary pattern 5 or ≥4 cores with sum 8–10 or multiple high-risk features	2.55	<0.001	1.68, 3.87	3.06	<0.001	1.82, 5.13	2.05	0.001	1.34, 3.13	138 (18.3%)
22	Primary pattern 5 or ≥5 cores with sum 8–10 or multiple high-risk features	3.21	<0.001	2.10, 4.89	3.54	<0.001	2.10, 5.96	2.39	<0.001	1.56, 3.67	114 (15.1%)
23	Primary pattern 5 or ≥6 cores with sum 8-10 or multiple high-risk features	3.22	<0.001	2.10, 4.96	3.74	<0.001	2.22, 6.30	2.52	<0.001	1.64, 3.87	102 (13.5%)
24	Primary pattern 5 or ≥7 cores with sum 8-10 or multiple high-risk features	3.35	<0.001	2.17, 5.17	3.90	<0.001	2.31, 6.57	2.63	<0.001	1.71, 4.03	94 (12.5%)
25	Primary pattern 5 or mult hi risk features or PNI	2.41	<0.001	1.65, 3.52	2.44	<0.001	1.50, 3.97	1.70	0.005	1.17, 2.46	257 (34.1%)
26	Primary pattern 5 or mult hi risk features or PNI+ ≥1 cores with Gleason sum 8–10	2.83	<0.001	1.90, 4.20	3.17	<0.001	1.92, 5.23	2.22	<0.001	1.49, 3.30	191 (25.4%)
27	Primary pattern 5 or mult hi risk features or PNI+ ≥2 cores with Gleason sum 8–10	3.04	<0.001	2.04, 4.53	3.20	<0.001	1.92, 5.31	2.15	<0.001	1.43, 3.25	152 (20.2%)
28	Primary pattern 5 or mult hi risk features or PNI+ ≥3 cores with Gleason sum 8–10	3.20	<0.001	2.12, 4.82	3.26	<0.001	1.94, 5.46	2.18	<0.001	1.43, 3.33	125 (16.6%)