Table 5.

Hazard ratios for metastasis and cancer-death comparing all possible CAPRA cut-points and JHH Very High Risk criteria, among 566 NCCN high-risk men with evaluable CAPRA scores, adjusted for age, year of surgery, and perineural invasion

	Metastasis				Cancer-specific mortality
Tested very-high-risk definitions	H.R.	p	95% C.I.	c-index	H.R.	p	95% C.I.	c-index	Very high risk sample size
CAPRA ≥4	2.81	0.305	0.39, 20.3	0.6100	1.12	0.913	0.15, 8.23	0.6599	540 (95.4%)
CAPRA ≥5	3.08	0.009	1.32, 7.18	0.6531	1.01	0.980	0.41, 2.49	0.6592	405 (71.6%)
CAPRA ≥6	2.48	0.001	1.47, 4.20	0.6487	1.40	0.351	0.69, 2.82	0.6553	231 (40.8%)
CAPRA ≥7	2.27	0.003	1.33, 3.87	0.6538	1.77	0.135	0.84, 3.73	0.6676	99 (17.5%)
CAPRA ≥8	1.65	0.220	0.74, 3.67	0.6161	2.00	0.134	0.81, 4.94	0.6560	34 (6.0%)
Primary pattern 5 or ≥5 cores with sum 8–10 or multiple high-risk features	2.26	0.005	1.28, 4.00	0.6413	2.35	0.031	1.08, 5.12	0.6874	93 (16.4%)