Table 2.
Predicted upstream regulators of genes altered by B[a]P treatment.
| Upstream Regulator | Predicted Activation State | Activation z-score | p-value of overlap |
|---|---|---|---|
| benzo(a)pyrene | Activated | 4.15 | 6.90E-23 |
| cigarette smoke | Activated | 2.80 | 1.22E-18 |
| cisplatin | Activated | 3.14 | 3.91E-15 |
| chromium | Inhibited | −4.24 | 5.51E-15 |
| camptothecin | Activated | 6.20 | 5.97E-15 |
| arsenite | 1.69 | 4.51E-14 | |
| tert-butyl-hydroquinone | Activated | 3.90 | 1.05E-13 |
| TP53 | Activated | 4.35 | 4.60E-13 |
| sulforafan | Activated | 2.05 | 7.47E-13 |
| nitric oxide | Activated | 4.26 | 4.27E-11 |
| PDGFBB | Activated | 2.97 | 6.69E-11 |
| FGF1 | Activated | 4.11 | 9.82E-11 |
| hydrogen peroxide | Activated | 3.34 | 1.59E-10 |
| HGF | −0.56 | 1.78E-10 | |
| NUPR1 | Activated | 3.43 | 2.59E-10 |
| BRCA1 | Activated | 2.17 | 3.96E-10 |
| U0126 | −1.56 | 4.61E-10 | |
| TNF | 1.83 | 6.13E-10 | |
| doxorubicin | Activated | 2.06 | 8.63E-10 |
| beta-naphthoflavone | Activated | 3.56 | 1.06E-09 |
| AHR | Activated | 2.96 | 2.07E-09 |
| tetrachlorodibenzodioxin | Activated | 3.58 | 2.12E-09 |
The z-score predicts activation state; the p-value measures the statistical significance of the prediction.