Table 3.
Predicted upstream regulators of genes altered by B[a]P treatment in cells exposed to 0.5 μM Cr(VI) for 20 passages
| Upstream Regulator | Predicted Activation State | Activation z-score | p-value of overlap |
|---|---|---|---|
| CD24 | Inhibited | −6.00 | 1.11E-18 |
| HGF | Inhibited | −7.11 | 3.81E-18 |
| Vegf | Inhibited | −7.92 | 2.17E-17 |
| camptothecin | Activated | 4.16 | 6.67E-14 |
| miR-124-3p ( miRNAs w/seed AAGGCAC) | Activated | 6.96 | 1.21E-12 |
| NUPRl | Activated | 4.12 | 6.75E-12 |
| miR-21-5p (miRNAs w/seed AGCUUAU) | Activated | 3.53 | 1.27E-11 |
| FSH | −1.27 | 1.62E-11 | |
| TP53 | 0.18 | 5.04E-11 | |
| Sos | 8.32E-11 | ||
| GNA12 | Inhibited | −4.54 | 5.52E-10 |
| TGFBl | Inhibited | −5.56 | 3.25E-09 |
| LMNA | 4.35E-09 | ||
| triamcinolone acetonide | 0.86 | 7.10E-09 | |
| miR-1 ( miRNAs w/seed GGAAUGU) | Activated | 6.32 | 8.87E-09 |
| methylselenic acid | Activated | 2.21 | 1.19E-08 |
| TGFB3 | Inhibited | −2.01 | 2.03E-08 |
| miR-17-5p (miRNAs w/seed AAAGUGC) | Activated | 3.44 | 2.29E-08 |
| AGT | −1.59 | 3.05E-08 | |
| HOXA9 | −1.81 | 3.37E-08 | |
| topotecan | Activated | 4.27 | 3.58E-08 |
The z-score predicts activation state; the p-value measures the statistical significance of the prediction.